Supergirl challenges Rhea to battle to save National City. Meanwhile, Superman returns and Cat Grant offers Supergirl some sage advice.
Supergirl struggles to decide whether or not to obey the President’s orders regarding Rhea’s latest actions. Meanwhile, Cat Grant returns to National City.
National City is attacked by a Phorian, a normally peaceful race with telekinetic abilities.
When Alex is kidnapped, Supergirl and Maggie must work together to save her.
Lena’s ex-boyfriend Jack Spheer comes to National City to reveal his breakthrough in nanotechnology that has the potential to eliminate all diseases.
Aliens attack National City with the intention of collecting a large bounty put out on Supergirl.
Supergirl goes on high alert when a new villain comes to National City. In other events, Winn’s new girlfriend gets him in trouble with the law and the Music Meister attacks.
Alex and Kara realize they must break the rules to foil Cadmus’ latest plot.
When Jeremiah Danvers is rescued from Cadmus, Alex and Kara are thrilled to have him back, but Mon-El is suspicious about his sudden return.
A magical imp called Mr. Mxyzptlk arrives on Earth and wreaks havoc on National City when Kara doesn’t reciprocate his feelings.
Lena is arrested when Metallo breaks Lillian out of prison and evidence suggests that Lena is responsible.
A White Martian called Armek comes to National City with the intention of bringing M’gann back to Mars to be punished for her treason.