A special military unit fights a powerful, out-of-control supercomputer and hundreds of scientists who have mutated into flesh-eating creatures after a laboratory accident.
When human forces discover the existence of the Vampire and Lycan clans, a war to eradicate both species commences. The vampire warrioress Selene leads the battle against humankind.
An origins story centered on the centuries-old feud between the race of aristocratic vampires and their onetime slaves, the Lycans.
Selene, a beautiful vampire warrior, is entrenched in a war between the vampire and werewolf races. Although she is aligned with the vampires, she falls in love with Michael, a werewolf who longs for the war to end.
Picking up directly from the previous film, vampire warrior Selena and the half werewolf Michael hunt for clues to reveal the history of their races and the war between them.